Meperidine and skin surface warming additively reduce the shivering threshold: a volunteer study
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چکیده
منابع مشابه
Meperidine and skin surface warming additively reduce the shivering threshold: a volunteer study
INTRODUCTION Mild therapeutic hypothermia has been shown to improve outcome for patients after cardiac arrest and may be beneficial for ischaemic stroke and myocardial ischaemia patients. However, in the awake patient, even a small decrease of core temperature provokes vigorous autonomic reactions-vasoconstriction and shivering-which both inhibit efficient core cooling. Meperidine and skin warm...
متن کاملDexmedetomidine and meperidine additively reduce the shivering threshold in humans.
BACKGROUND AND PURPOSE Hypothermia might prove to be therapeutically beneficial in stroke victims; however, even mild hypothermia provokes vigorous shivering. Meperidine and dexmedetomidine each linearly reduce the shivering threshold (triggering core temperature) with minimal sedation. We tested the hypothesis that meperidine and dexmedetomidine synergistically reduce the shivering threshold w...
متن کاملNefopam and alfentanil additively reduce the shivering threshold in humans whereas nefopam and clonidine do not.
BACKGROUND Induction of therapeutic hypothermia is often complicated by shivering. Nefopam reduces the shivering threshold with minimal side effects. Consequently, nefopam is an attractive component for induction of therapeutic hypothermia. However, nefopam alone is insufficient; it will thus need to be combined with another drug. Clonidine and alfentanil each reduce the shivering threshold. Th...
متن کاملPethidine and skin warming to prevent shivering during endovascular cooling.
We tested the efficacy of pethidine and cutaneous warming to prevent shivering during percutaneous cooling in unanaesthetized patients. Ten patients scheduled for cranial neurosurgery received pethidine infusion and skin warming. The Setpoint internal heat-exchanging catheter was inserted and cooling to 33.5 degrees C was started. Clonidine and chlorpromazine were given as "rescue medication" t...
متن کاملOndansetron does not reduce the shivering threshold in healthy volunteers.
BACKGROUND Ondansetron, a serotonin-3 receptor antagonist, reduces postoperative shivering. Drugs that reduce shivering usually impair central thermoregulatory control, and may thus be useful for preventing shivering during induction of therapeutic hypothermia. We determined, therefore, whether ondansetron reduces the major autonomic thermoregulatory response thresholds (triggering core tempera...
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ژورنال
عنوان ژورنال: Critical Care
سال: 2007
ISSN: 1364-8535
DOI: 10.1186/cc5709